I've been giving this some thought and my choices might work better animated than live action. That said:
1. Marvel Zombies. If you've read the series you know why I'm suggesting that this would be one of the boldest, and most entertaining Marvel adaptations yet! A well-deserved hard 'R,' enough gore to satisfy the most bloodthirsty horror fanatics but a great mix of comedy to make it feel like 'Dead Alive' or 'Brain Dead.' Just cool!
2. Juan Diaz Canales & Juanjo Guarnido's anthropomorphic film noir classic series 'Blacksad.'
'Blacksad' is hard to find but is worth tracking down. On the theme of crime and film noir, I'd also like to see Brian Azzarello's '100 Bullets.' I had another one I was thinking about but it has left my mind. I'll make an additional post if it comes back to me.